Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells

Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells

Abstract Radiation therapy is a common treatment modality for lung cancer, and resistance to radiation can significantly affect treatment outcomes. We recently described that lung cancer cells that express more germ cell cancer genes (GC genes, genes that are usually restricted to the germ line) can...

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Bibliographic Details
Main Authors: Wenqing Liu, Qijing Lei, Ans M. M. van Pelt, Geert Hamer
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Non-small cell lung cancer (NSCLC)
Cancer treatment
Irradiation
Homologous recombination
Germ cell cancer genes (GC genes)
TRIP13
Online Access:https://doi.org/10.1038/s41598-024-84592-w
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https://doi.org/10.1038/s41598-024-84592-w

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