Ancestry-linked stromal variations impact breast epithelial cell invasion

Summary: Breast cancer disproportionately affects women of African ancestry (AA) in part due to biological factors that affect disease outcome. A cell population that expresses PROCR, ZEB1, and PDGFRα (PZP) was recently found to be enriched in breast stroma from healthy AA donors, but only in tumor-...

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Bibliographic Details
Main Authors: Madison G. Schmidtmann, Victoria Elliott, James W. Clancy, Zachary T. Schafer, Harikrishna Nakshatri, Crislyn D’Souza-Schorey
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225009472
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