Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair

Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair

Abstract Glioblastoma (GBM) is the most common malignant primary brain cancer with poor prognosis due to the resistant to current treatments, including the first-line drug temozolomide (TMZ). Accordingly, it is urgent to clarify the mechanism of chemotherapeutic resistance to improve the survival ra...

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Bibliographic Details
Main Authors: Yuchen Wei, Peng Wang, Jianhui Zhao, Xin Fan, Jun Jiang, Xiuli Mu, Yuzhou Wang, Angang Yang, Rui Zhang, Shijie Hu, Zhangyan Guo
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07363-z
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