Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease
This study examined whether there were neuroanatomical differences evident on CT scans of individuals with dementia who differed on depression history. Neuroanatomical variables consisted of visual ratings of frontal lobe deep white matter, subcortical white matter, and subcortical gray matter hypod...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/187219 |
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| _version_ | 1832558130650677248 |
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| author | Jessica A. Brommelhoff Bryan M. Spann John L. Go Wendy J. Mack Margaret Gatz |
| author_facet | Jessica A. Brommelhoff Bryan M. Spann John L. Go Wendy J. Mack Margaret Gatz |
| author_sort | Jessica A. Brommelhoff |
| collection | DOAJ |
| description | This study examined whether there were neuroanatomical differences evident on CT scans of individuals with dementia who differed on depression history. Neuroanatomical variables consisted of visual ratings of frontal lobe deep white matter, subcortical white matter, and subcortical gray matter hypodensities in the CT scans of 182 individuals from the Study of Dementia in Swedish Twins who were diagnosed with dementia and had information on depression history. Compared to individuals with Alzheimer's disease and no depression, individuals with Alzheimer's disease and late-onset depression (first depressive episode at age 60 or over) had a greater number of striatal hypodensities (gray matter hypodensities in the caudate nucleus and lentiform nucleus). There were no significant differences in frontal lobe deep white matter or subcortical white matter. These findings suggest that late-onset depression may be a process that is distinct from the neurodegenerative changes caused by Alzheimer's disease. |
| format | Article |
| id | doaj-art-c09829dbe7b74e3b9f2d43349f45b22f |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-c09829dbe7b74e3b9f2d43349f45b22f2025-02-03T01:33:16ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/187219187219Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's DiseaseJessica A. Brommelhoff0Bryan M. Spann1John L. Go2Wendy J. Mack3Margaret Gatz4Department of Psychology, University of Southern California, Los Angeles, CA 90089, USADepartment of Neurology, University of Southern California, Los Angeles, CA 90033, USADepartment of Radiology, University of Southern California, Los Angeles, CA 90033, USADepartment of Preventive Medicine, University of Southern California, Los Angeles, CA 90089, USADepartment of Psychology, University of Southern California, Los Angeles, CA 90089, USAThis study examined whether there were neuroanatomical differences evident on CT scans of individuals with dementia who differed on depression history. Neuroanatomical variables consisted of visual ratings of frontal lobe deep white matter, subcortical white matter, and subcortical gray matter hypodensities in the CT scans of 182 individuals from the Study of Dementia in Swedish Twins who were diagnosed with dementia and had information on depression history. Compared to individuals with Alzheimer's disease and no depression, individuals with Alzheimer's disease and late-onset depression (first depressive episode at age 60 or over) had a greater number of striatal hypodensities (gray matter hypodensities in the caudate nucleus and lentiform nucleus). There were no significant differences in frontal lobe deep white matter or subcortical white matter. These findings suggest that late-onset depression may be a process that is distinct from the neurodegenerative changes caused by Alzheimer's disease.http://dx.doi.org/10.4061/2011/187219 |
| spellingShingle | Jessica A. Brommelhoff Bryan M. Spann John L. Go Wendy J. Mack Margaret Gatz Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease Journal of Aging Research |
| title | Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease |
| title_full | Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease |
| title_fullStr | Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease |
| title_full_unstemmed | Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease |
| title_short | Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease |
| title_sort | striatal hypodensities not white matter hypodensities on ct are associated with late onset depression in alzheimer s disease |
| url | http://dx.doi.org/10.4061/2011/187219 |
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