Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer

Platinum drugs upregulate CXCR4 and PD‐L1 expression via ROS‐dependent pathways, with implications for novel combined treatment in gastric cancer

Abstract CXC chemokine receptor 4 (CXCR4) and programmed cell death‐ligand 1 (PD‐L1) are two critical molecules involved in the tumor immune microenvironment. However, the impact of platinum drugs, such as cisplatin, on CXCR4 or PD‐L1 expression and the underlying mechanisms in gastric cancer (GC) r...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiaoyu Kang, Lin Zhang, Shushang Liu, Fei Wang, Haiming Liu, Fenli Zhou, Fei Wu, Haohao Zhang, Daiming Fan, Yongzhan Nie, Zhangqian Chen
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:The Journal of Pathology: Clinical Research
Subjects:
CXCR4
PD‐L1
gastric cancer
cisplatin
treatment strategy
Online Access:https://doi.org/10.1002/2056-4538.70015
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/2056-4538.70015

Similar Items