Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity

Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity

Summary: Transforming growth factor β1 (TGF-β1) is an immunosuppressive cytokine produced as a latent homodimer, in which mature TGF-β1 is encapsulated and kept inactive by the latency-associated peptide (LAP). The transmembrane protein GARP presents latent TGF-β1 on the surface of regulatory T cell...

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Main Authors: Fanny Lambert, Jan Felix, Séverine Wautier, Emilie Dupré, Mathieu Jamez, Camille Michiels, Mélanie Gaignage, Lore Mariën, Manon Lesage, Bas van der Woning, Savvas N. Savvides, Sophie Lucas
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008320
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http://www.sciencedirect.com/science/article/pii/S2211124725008320

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