Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors

Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors

The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention among such approaches. Lipoxygenase (LOX) is one owf the mo...

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Bibliographic Details
Main Authors: V. V. Stavytskyi, I. S. Nosulenko, O. O. Portna, V. M. Shvets, O. Yu. Voskoboynik, S. І. Kоvalenko
Format: Article
Language:English
Published: Zaporizhzhia State Medical and Pharmaceutical University 2020-05-01
Series:Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Subjects:
drug discovery
pyrrolo[1 2-a][1 2 4]triazolo-(triazino-)[c]quinazolines
molecular docking
lipoxygenase activity
Online Access:http://pharmed.zsmu.edu.ua/article/view/198109/199112
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