APOE genetic variability in an Egyptian cohort of PD

APOE genetic variability in an Egyptian cohort of PD

BackgroundThe apolipoprotein E (APOE) gene, encompassing three alleles (ε2, ε3, ε4), is a critical player in lipid metabolism and has been extensively studied for its role in neurodegenerative diseases. This study examines APOE genetic variability and its association with PD in an Egyptian cohort.Me...

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Main Authors: Eman M. Khedr, Martina B. William, Aliaa A. Elhosseiny, Ali Shalash, Gharib Fawi, Mohamed H. Yousef, Shaimaa El-Jaafary, Hamin Lee, Alina Jama, Mohamed Koraym, Asmaa Helmy, Yara Salah, Peter George, Nourelhoda A. Haridy, Samir Nabhan, Agsha Atputhavadivel, Sara Elfarrash, Gaafar Ragab, Mohamed Tharwat Hegazy, Yasmin Elsaid, Asmaa S. Gabr, Nourhan Shebl, Lobna Aly, Nesreen Abdelwahhab, Tamer M. Belal, Nehal A. B. Elsayed, Mohamed El-Gamal, Shimaa Elgamal, Salma Ragab, Jaidaa Mekky, Henry Houlden, Mie Rizig, Mohamed Salama
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s disease
genetics
APOE
KASP
Egyptian
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1579968/full
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Summary:BackgroundThe apolipoprotein E (APOE) gene, encompassing three alleles (ε2, ε3, ε4), is a critical player in lipid metabolism and has been extensively studied for its role in neurodegenerative diseases. This study examines APOE genetic variability and its association with PD in an Egyptian cohort.MethodsA total of 891 participants, including 422 PD patients and 469 healthy controls, were included in this study. APOE genotyping was performed using Kompetitive Allele Specific PCR (KASP) to detect the rs429358 and rs7412 SNPs, which define the APOE alleles. APOE alleles were categorized based on the genotypes into ε2, ε3, and ε4 groups. Clinical assessments of PD patients included age at onset, disease severity (MDS-UPDRS), and demographic factors. Statistical analyses compared APOE distributions between PD and control groups and examined associations with clinical variables.ResultsThe ε3 allele was the most prevalent in the cohort (77.3%), aligning with global and African trends. The ε2 allele was observed in 11.4%, and the ε4 allele in 11.3%, with both frequencies being lower than reported African estimates. The ε3/ε3 genotype was predominant in both PD patients (72.51%) and controls (72.07%). The ε4/ε4 genotype was absent in PD cases and rare among controls (0.64%). No significant association was found between APOE genotypes and PD risk, age at onset, or disease severity.ConclusionOur findings do not support a significant role for APOE in PD susceptibility or severity in Egyptians.
ISSN:1662-453X

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