The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.

The MacBlue binary transgene (csf1r-gal4VP16/UAS-ECFP) provides a novel marker for visualisation of subsets of monocytes, macrophages and dendritic cells and responsiveness to CSF1 administration.

The MacBlue transgenic mouse uses the Csf1r promoter and first intron to drive expression of gal4-VP16, which in turn drives a cointegrated gal4-responsive UAS-ECFP cassette. The Csf1r promoter region used contains a deletion of a 150 bp conserved region covering trophoblast and osteoclast-specific...

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Main Authors: Kristin A Sauter, Clare Pridans, Anuj Sehgal, Calum C Bain, Charlotte Scott, Lindsey Moffat, Rocío Rojo, Ben M Stutchfield, Claire L Davies, David S Donaldson, Kathleen Renault, Barry W McColl, Alan M Mowat, Alan Serrels, Margaret C Frame, Neil A Mabbott, David A Hume
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0105429
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