Real-practice thromboprophylaxis in atrial fibrillation
This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0016 |
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| author | Deambrosis Paola Bettiol Alessandra Bolcato Jenny Pirolo Roberta Franchin Giulia Themistoclakis Sakis Pellizzari Michele Chinellato Alessandro Giusti Pietro |
| author_facet | Deambrosis Paola Bettiol Alessandra Bolcato Jenny Pirolo Roberta Franchin Giulia Themistoclakis Sakis Pellizzari Michele Chinellato Alessandro Giusti Pietro |
| author_sort | Deambrosis Paola |
| collection | DOAJ |
| description | This retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of 6,138 NVAF patients, only 3,024 received vitamin K antagonist (VKA). Potential barriers decreasing the probability of being treated with VKA were female sex, older age, antiplatelet treatment and history of bleeding. In addition, VKA-treatment was not in line with current ESC and AIAC guidelines, since the patients at high or low risk of stroke were under- or over-treated, resp. Among VKAtreated patients, 73 % of subjects were not at target with anticoagulation. OAT resulted to be effective in reducing stroke risk. However, stroke events were significantly influenced also by previous stroke or transient ischemic attack (hazard ratio, HR = 2.99, p < 0.001) and by previous bleeding events (HR = 1.60, p < 0.001). |
| format | Article |
| id | doaj-art-c03be3ff7efc4d3cabe805c05c26b6a8 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-c03be3ff7efc4d3cabe805c05c26b6a82025-02-02T10:06:42ZengSciendoActa Pharmaceutica1846-95582017-06-0167222723610.1515/acph-2017-0016acph-2017-0016Real-practice thromboprophylaxis in atrial fibrillationDeambrosis Paola0Bettiol Alessandra1Bolcato Jenny2Pirolo Roberta3Franchin Giulia4Themistoclakis Sakis5Pellizzari Michele6Chinellato Alessandro7Giusti Pietro8Department of Pharmaceutical and Pharmacological Science University of Padua, 35131, Padua, ItalyDepartment of Pharmaceutical and Pharmacological Science University of Padua, 35131, Padua, ItalyLocal Health Authority n.9 of Treviso, Pharmaceutical Service 31100, Treviso, ItalyLocal Health Authority n.9 of Treviso, Pharmaceutical Service 31100, Treviso, ItalyLocal Health Authority n.9 of Treviso, Pharmaceutical Service 31100, Treviso, ItalyLocal Health Authority n.12 of Venezia Hospital Unit of Electrophysiology and Electrostimulation Dell’Angelo Hospital, 30174, Mestre, ItalyVeneto Region, Regional Epidemiological Centre 35131, Padova, ItalyLocal Health Authority n.9 of Treviso, Pharmaceutical Service 31100, Treviso, ItalyDepartment of Pharmaceutical and Pharmacological Science University of Padua, 35131, Padua, ItalyThis retrospective observational study was based on databases of the Local Health Authority of Treviso, Italy. It evaluated the prevalence and the effectiveness of oral anticoagulation treatment (OAT) for the management of nonvalvular atrial fibrillation (NVAF) in everyday clinical practice. Out of 6,138 NVAF patients, only 3,024 received vitamin K antagonist (VKA). Potential barriers decreasing the probability of being treated with VKA were female sex, older age, antiplatelet treatment and history of bleeding. In addition, VKA-treatment was not in line with current ESC and AIAC guidelines, since the patients at high or low risk of stroke were under- or over-treated, resp. Among VKAtreated patients, 73 % of subjects were not at target with anticoagulation. OAT resulted to be effective in reducing stroke risk. However, stroke events were significantly influenced also by previous stroke or transient ischemic attack (hazard ratio, HR = 2.99, p < 0.001) and by previous bleeding events (HR = 1.60, p < 0.001).https://doi.org/10.1515/acph-2017-0016atrial fibrillationthromboprophylaxisrealpracticevitamin k antagonistsstroke risk |
| spellingShingle | Deambrosis Paola Bettiol Alessandra Bolcato Jenny Pirolo Roberta Franchin Giulia Themistoclakis Sakis Pellizzari Michele Chinellato Alessandro Giusti Pietro Real-practice thromboprophylaxis in atrial fibrillation Acta Pharmaceutica atrial fibrillation thromboprophylaxis realpractice vitamin k antagonists stroke risk |
| title | Real-practice thromboprophylaxis in atrial fibrillation |
| title_full | Real-practice thromboprophylaxis in atrial fibrillation |
| title_fullStr | Real-practice thromboprophylaxis in atrial fibrillation |
| title_full_unstemmed | Real-practice thromboprophylaxis in atrial fibrillation |
| title_short | Real-practice thromboprophylaxis in atrial fibrillation |
| title_sort | real practice thromboprophylaxis in atrial fibrillation |
| topic | atrial fibrillation thromboprophylaxis realpractice vitamin k antagonists stroke risk |
| url | https://doi.org/10.1515/acph-2017-0016 |
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