NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections

5-Methylcytosine (m5C) is a widespread post-transcriptional RNA modification and is reported to be involved in manifold cellular responses and biological processes through regulating RNA metabolism. However, its regulatory role in antiviral innate immunity has not yet been elucidated. Here, we repor...

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Bibliographic Details
Main Authors: Hongyun Wang, Jiangpeng Feng, Cong Zeng, Jiejie Liu, Zhiying Fu, Dehe Wang, Yafen Wang, Lu Zhang, Jiali Li, Ao Jiang, Miao He, Yuanyuan Cao, Kun Yan, Hao Tang, Deyin Guo, Ke Xu, Xiang Zhou, Li Zhou, Ke Lan, Yu Zhou, Yu Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
5-methylcytosine
RNA methyltransferase
viral infections
antiviral innate immunity
SARS-CoV-2
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2178238
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https://www.tandfonline.com/doi/10.1080/22221751.2023.2178238

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