Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling

Hypoxia‐induced PGK1 expression promotes esophageal squamous cell carcinoma progression via stimulating MYH9‐mediated GSK3β/β‐catenin signalling

Abstract Background Phosphoglycerate kinase 1 (PGK1) serves as a critical metabolic enzyme in the process of glycolysis and has many nonmetabolic functions in tumour progression. One of the most prevalent malignant tumours is still esophageal squamous cell carcinoma (ESCC), with high recurrence rate...

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Bibliographic Details
Main Authors: Jia‐cheng Xu, Lin‐feng Wu, Tian‐yin Chen, Yan‐bo Liu, Yi‐fei Zhang, Ping‐hong Zhou, Yi‐qun Zhang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Clinical and Translational Medicine
Subjects:
β‐catenin signalling pathway
esophageal squamous cell carcinoma
hypoxia
MYH9
PGK1
Online Access:https://doi.org/10.1002/ctm2.70376
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