Credibility assessment of a mechanistic model of atherosclerosis to predict cardiovascular outcomes under lipid-lowering therapy

Credibility assessment of a mechanistic model of atherosclerosis to predict cardiovascular outcomes under lipid-lowering therapy

Abstract Demonstrating cardiovascular (CV) benefits with lipid-lowering therapy (LLT) requires long-term randomized clinical trials (RCTs) with thousands of patients. Innovative approaches such as in silico trials applying a disease computational model to virtual patients receiving multiple treatmen...

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Main Authors: Yishu Wang, Eulalie Courcelles, Emmanuel Peyronnet, Solène Porte, Alizée Diatchenko, Evgueni Jacob, Denis Angoulvant, Pierre Amarenco, Franck Boccara, Bertrand Cariou, Guillaume Mahé, Philippe Gabriel Steg, Alexandre Bastien, Lolita Portal, Jean-Pierre Boissel, Solène Granjeon-Noriot, Emmanuelle Bechet
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-025-01557-7
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https://doi.org/10.1038/s41746-025-01557-7

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