Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy
Renal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. Some patients with metastatic renal cell carcinoma are found in advanced stages, so the 5-year survival rate for metastatic renal cell carcinoma is only 14%. Currently, ther...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1521151/full |
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| author | Xinwei Li Xinwei Li Wei Xiong Zhiyong Xiong Zhiyong Xiong Xiaoping Zhang Xiaoping Zhang Xiaoping Zhang |
| author_facet | Xinwei Li Xinwei Li Wei Xiong Zhiyong Xiong Zhiyong Xiong Xiaoping Zhang Xiaoping Zhang Xiaoping Zhang |
| author_sort | Xinwei Li |
| collection | DOAJ |
| description | Renal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. Some patients with metastatic renal cell carcinoma are found in advanced stages, so the 5-year survival rate for metastatic renal cell carcinoma is only 14%. Currently, there are several drugs available for patients with metastatic renal cell carcinoma, and their overall survival can be extended to nearly 5 years. However, the sensitivity and efficacy of the treatment are still unsatisfactory. New targets and drugs to improve patient prognosis are urgently needed, but these are closely linked to the molecular mechanisms of renal cell carcinoma metastasis. In this review, we present the definition and common molecular mechanisms of metastatic renal cell carcinoma and provide new insights on their potential link to targeted therapies, which may enlighten scientists to develop future targeted therapeutic agents to improve the prognosis of patients with metastatic renal cell carcinoma. |
| format | Article |
| id | doaj-art-bff69f6f07dc4866b1b9b615010bb7a5 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-bff69f6f07dc4866b1b9b615010bb7a52025-01-20T07:20:05ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011310.3389/fcell.2025.15211511521151Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapyXinwei Li0Xinwei Li1Wei Xiong2Zhiyong Xiong3Zhiyong Xiong4Xiaoping Zhang5Xiaoping Zhang6Xiaoping Zhang7Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaShenzhen Huazhong University of Science and Technology Research Institute, Shenzhen, ChinaRenal cell carcinoma is a common type of cancer, with approximately 30% of patients potentially developing metastatic disease. Some patients with metastatic renal cell carcinoma are found in advanced stages, so the 5-year survival rate for metastatic renal cell carcinoma is only 14%. Currently, there are several drugs available for patients with metastatic renal cell carcinoma, and their overall survival can be extended to nearly 5 years. However, the sensitivity and efficacy of the treatment are still unsatisfactory. New targets and drugs to improve patient prognosis are urgently needed, but these are closely linked to the molecular mechanisms of renal cell carcinoma metastasis. In this review, we present the definition and common molecular mechanisms of metastatic renal cell carcinoma and provide new insights on their potential link to targeted therapies, which may enlighten scientists to develop future targeted therapeutic agents to improve the prognosis of patients with metastatic renal cell carcinoma.https://www.frontiersin.org/articles/10.3389/fcell.2025.1521151/fullrenal cell carcinomametastasismetastatic renal cell carcinomamolecular mechanismstargeted therapy |
| spellingShingle | Xinwei Li Xinwei Li Wei Xiong Zhiyong Xiong Zhiyong Xiong Xiaoping Zhang Xiaoping Zhang Xiaoping Zhang Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy Frontiers in Cell and Developmental Biology renal cell carcinoma metastasis metastatic renal cell carcinoma molecular mechanisms targeted therapy |
| title | Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy |
| title_full | Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy |
| title_fullStr | Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy |
| title_full_unstemmed | Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy |
| title_short | Molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy |
| title_sort | molecular mechanisms of renal cell carcinoma metastasis and potential targets for therapy |
| topic | renal cell carcinoma metastasis metastatic renal cell carcinoma molecular mechanisms targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1521151/full |
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