Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System
Aim. To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods. Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/1267475 |
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| author | Rengna Yan Yun Hu Fengfei Li Lanlan Jiang Xiaohua Xu Jie Wang Ying Zhang Lei Ye Kok Onn Lee Xiaofei Su Jianhua Ma |
| author_facet | Rengna Yan Yun Hu Fengfei Li Lanlan Jiang Xiaohua Xu Jie Wang Ying Zhang Lei Ye Kok Onn Lee Xiaofei Su Jianhua Ma |
| author_sort | Rengna Yan |
| collection | DOAJ |
| description | Aim. To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods. Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or IGT/IFG. The incremental area under the curve (AUC) above a glucose value of 6.1 mmol/L or FG glucose levels were calculated to evaluate the contributions of PG or FG to HbA1c values. Results. According to quintiles of HbA1c, T2D patients were divided into five groups (group 1 to 5), and patients with IGT/IFG were assigned into group 0. PG was the predominant contributor in the lower groups with HbA1c 4.9∼6.0% and 6.1∼7.8%. The relative contributions of FG and PG to HbA1c had no significance in the middle groups of HbA1c (7.9∼8.7% and 8.8∼9.5%). FG contributed significantly more than PG in the higher groups of HbA1c (9.6∼10.9% and 11.0∼14.6%). Regression analyses indicate that the contributions of FG and PG were equal (both 50%) when the level of HbA1c was 8.5%. Conclusions. In drug-naïve patients with T2D or IGT/IFG, PG contributed more in patients with HbA1c < 8.5%, whereas FG became the predominant contributor in the poorly controlled patients with HbA1c ≥ 8.5%. These results may help the health-care provider set appropriate plasma glucose testing goals with the expectation of achieving specific HbA1c values. |
| format | Article |
| id | doaj-art-bfe30b8af4c744b0a16f783d61d39f50 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-bfe30b8af4c744b0a16f783d61d39f502025-02-03T05:48:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/12674751267475Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring SystemRengna Yan0Yun Hu1Fengfei Li2Lanlan Jiang3Xiaohua Xu4Jie Wang5Ying Zhang6Lei Ye7Kok Onn Lee8Xiaofei Su9Jianhua Ma10Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaNational Heart Research Institute Singapore, National Heart Centre Singapore, 169609, SingaporeDepartment of Medicine, National University of Singapore, 119228, SingaporeDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaDepartment of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210012, ChinaAim. To clarify the contributions of fasting glucose (FG) and postprandial glucose (PG) to HbA1c in drug-naïve patients with type 2 diabetes (T2D) and impaired glucose tolerate (IGT)/impaired fasting glucose (IFG). Methods. Continuous glucose monitoring (CGM) was performed in 305 drug-naïve Chinese patients with T2D or IGT/IFG. The incremental area under the curve (AUC) above a glucose value of 6.1 mmol/L or FG glucose levels were calculated to evaluate the contributions of PG or FG to HbA1c values. Results. According to quintiles of HbA1c, T2D patients were divided into five groups (group 1 to 5), and patients with IGT/IFG were assigned into group 0. PG was the predominant contributor in the lower groups with HbA1c 4.9∼6.0% and 6.1∼7.8%. The relative contributions of FG and PG to HbA1c had no significance in the middle groups of HbA1c (7.9∼8.7% and 8.8∼9.5%). FG contributed significantly more than PG in the higher groups of HbA1c (9.6∼10.9% and 11.0∼14.6%). Regression analyses indicate that the contributions of FG and PG were equal (both 50%) when the level of HbA1c was 8.5%. Conclusions. In drug-naïve patients with T2D or IGT/IFG, PG contributed more in patients with HbA1c < 8.5%, whereas FG became the predominant contributor in the poorly controlled patients with HbA1c ≥ 8.5%. These results may help the health-care provider set appropriate plasma glucose testing goals with the expectation of achieving specific HbA1c values.http://dx.doi.org/10.1155/2019/1267475 |
| spellingShingle | Rengna Yan Yun Hu Fengfei Li Lanlan Jiang Xiaohua Xu Jie Wang Ying Zhang Lei Ye Kok Onn Lee Xiaofei Su Jianhua Ma Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System International Journal of Endocrinology |
| title | Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System |
| title_full | Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System |
| title_fullStr | Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System |
| title_full_unstemmed | Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System |
| title_short | Contributions of Fasting and Postprandial Glucose Concentrations to Haemoglobin A1c in Drug-Naïve Mal-Glucose Metabolism in Chinese Population Using Continuous Glucose Monitoring System |
| title_sort | contributions of fasting and postprandial glucose concentrations to haemoglobin a1c in drug naive mal glucose metabolism in chinese population using continuous glucose monitoring system |
| url | http://dx.doi.org/10.1155/2019/1267475 |
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