Effect of Process Parameters on Nano-Microparticle Formation During Supercritical Antisolvent Process Using Mixed Solvent: Application for Enhanced Dissolution and Oral Bioavailability of Telmisartan Through Particle-Size Control Based on Experimental Design

Effect of Process Parameters on Nano-Microparticle Formation During Supercritical Antisolvent Process Using Mixed Solvent: Application for Enhanced Dissolution and Oral Bioavailability of Telmisartan Through Particle-Size Control Based on Experimental Design

<b>Background/Objectives:</b> This study investigates the impact of supercritical antisolvent (SAS) process parameters on the particle formation of telmisartan, a poorly water-soluble drug. <b>Methods:</b> A fractional factorial design was employed to examine the influence of...

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Bibliographic Details
Main Authors: Eun-Sol Ha, Heejun Park, Ji-Su Jeong, Seon-Kwang Lee, Hui-Taek Kang, In-hwan Baek, Min-Soo Kim
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
supercritical antisolvent process
nano-microparticles
bioavailability
telmisartan
Online Access:https://www.mdpi.com/1999-4923/16/12/1508
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