The molecular mechanism of PLD2-mediated regulation of apoptosis and cell edema in pancreatic cells via the Nrf2/NF-κB pathway

The molecular mechanism of PLD2-mediated regulation of apoptosis and cell edema in pancreatic cells via the Nrf2/NF-κB pathway

Abstract This study aimed to elucidate the molecular mechanisms by which PLD2 controls apoptosis and edema in pancreatic cells via the Nrf2/NF-κB pathway. AR42J rat pancreatic cells were treated with 10 nM mitomycin to create an in vitro pancreatitis model (model group), with a control group receivi...

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Bibliographic Details
Main Authors: Rui Zhou, Yuan Fan, Hailong Wu, Shuiping Zhan, Jun Shen, Meng Zhu
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Phospholipase D2
Nrf2/NF-κB
Pancreatic cells
Pan-apoptosis
Cell edema
Online Access:https://doi.org/10.1038/s41598-024-76274-4
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https://doi.org/10.1038/s41598-024-76274-4

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