The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the most serious complications of diabetic microangiopathy. DR has an early onset and is not easy to detect. When visual impairment occurs, the optimal period for therapy is often missed. Therefore, the prevention and treatment of DR should start from the early st...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8867875 |
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| _version_ | 1832550098197807104 |
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| author | Wenjun Sha Song Wen Lin Chen Bilin Xu Tao Lei Ligang Zhou |
| author_facet | Wenjun Sha Song Wen Lin Chen Bilin Xu Tao Lei Ligang Zhou |
| author_sort | Wenjun Sha |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is one of the most serious complications of diabetic microangiopathy. DR has an early onset and is not easy to detect. When visual impairment occurs, the optimal period for therapy is often missed. Therefore, the prevention and treatment of DR should start from the early stage of diabetes. Sodium-dependent glucose transporter 2 inhibitor (SGLT2i) is a new antidiabetic drug which is mainly used in clinical practice to control blood glucose of patients with type 2 diabetes prone to develop chronic heart failure. Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy. |
| format | Article |
| id | doaj-art-bf7ff8c6ebc943729ed3f994859a375b |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-bf7ff8c6ebc943729ed3f994859a375b2025-02-03T06:07:40ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/88678758867875The Role of SGLT2 Inhibitor on the Treatment of Diabetic RetinopathyWenjun Sha0Song Wen1Lin Chen2Bilin Xu3Tao Lei4Ligang Zhou5Department of Endocrinology and Metabolism, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, ChinaDepartment of Endocrinology and Metabolism, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Endocrinology and Metabolism, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Endocrinology and Metabolism, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, ChinaDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, ChinaDiabetic retinopathy (DR) is one of the most serious complications of diabetic microangiopathy. DR has an early onset and is not easy to detect. When visual impairment occurs, the optimal period for therapy is often missed. Therefore, the prevention and treatment of DR should start from the early stage of diabetes. Sodium-dependent glucose transporter 2 inhibitor (SGLT2i) is a new antidiabetic drug which is mainly used in clinical practice to control blood glucose of patients with type 2 diabetes prone to develop chronic heart failure. Recent studies have found that SGLT2 is also expressed in the human retina. Now, the prevention and treatment of diabetic retinopathy with SGLT2i while reducing blood sugar has become a new research field. Hence, this article reviewed the recent therapeutic and research progress of SGLT2 in the treatment of diabetic retinopathy.http://dx.doi.org/10.1155/2020/8867875 |
| spellingShingle | Wenjun Sha Song Wen Lin Chen Bilin Xu Tao Lei Ligang Zhou The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy Journal of Diabetes Research |
| title | The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy |
| title_full | The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy |
| title_fullStr | The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy |
| title_full_unstemmed | The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy |
| title_short | The Role of SGLT2 Inhibitor on the Treatment of Diabetic Retinopathy |
| title_sort | role of sglt2 inhibitor on the treatment of diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2020/8867875 |
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