Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion

Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion

Summary: Environmental exposures significantly influence cancer risk, but their mutational impact remains unclear. We perform whole-exome sequencing of hepatocellular carcinomas (HCCs) from B6C3F1/N mice that arise spontaneously with age (2 years old) or following chronic exposure to one of ten pote...

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Main Authors: Miaofei Xu, Jianying Li, Yun-Chung Hsiao, Ramesh C. Kovi, Jian-Liang Li, Leszek J. Klimczak, Laura Riva, David Adams, Pierre R. Bushel, B. Alex Merrick, Dmitry Gordenin, John R. Bucher, Robert C. Sills, Arun R. Pandiri
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007491
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