Dihydroartemisinin decreases pre-existing neutralizing antibodies against adeno-associated virus in challenged mice

Dihydroartemisinin decreases pre-existing neutralizing antibodies against adeno-associated virus in challenged mice

IntroductionThe high prevalence of pre-existing neutralizing antibodies (NAbs) against adeno-associated virus (AAV) poses a major obstacle to in vivo gene therapy. Current immunosuppressive (IS) strategies, such as corticosteroids, are limited by toxicity and adverse effects. To explore safer altern...

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Bibliographic Details
Main Authors: Jingjing Fang, Enze Cui, Jinyan Xie, Xuxia Gao, Yun He, Ming Yang, Sana Shaheen, Zhengjun Zhou, Shaolai Zhou, Binbin Cheng, Changquan Ling, Chen Ling
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
gene therapy
adeno-associated virus vector
neutralizing antibody
immunosuppression agents
traditional Chinese medicine
dihydroartemisinin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1587135/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1587135/full

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