Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia
A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. Clinical remission was achieved, while B-cell clonality remained. Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (flud...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/9710790 |
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| author | Hidekazu Nishikii Naoki Kurita Atsushi Shinagawa Tatsuhiro Sakamoto Manabu Kusakabe Yasuhisa Yokoyama Takayasu Kato Mamiko Sakata-Yanagimoto Naoshi Obara Yuichi Hasegawa Naoya Nakamura Shigeru Chiba |
| author_facet | Hidekazu Nishikii Naoki Kurita Atsushi Shinagawa Tatsuhiro Sakamoto Manabu Kusakabe Yasuhisa Yokoyama Takayasu Kato Mamiko Sakata-Yanagimoto Naoshi Obara Yuichi Hasegawa Naoya Nakamura Shigeru Chiba |
| author_sort | Hidekazu Nishikii |
| collection | DOAJ |
| description | A 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. Clinical remission was achieved, while B-cell clonality remained. Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (fludarabine and 2-Gy total body irradiation). However, autologous hematopoietic recovery occurred within a month after the transplant. Nevertheless, B-cell clonality became undetectable at 14 days after transplant, which has been kept so for over 10 years with clinical remission. Cytogenetic analyses were repeatedly performed and demonstrated nonclonal chromosomal aberrations, although the patient did not develop any secondary malignancies. One possible explanation for the clinical course is a very short-term allogeneic immune reaction helping eradication of residual CLL cells. |
| format | Article |
| id | doaj-art-bef8eb0569c7426d9c6f139d583a4b7c |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-bef8eb0569c7426d9c6f139d583a4b7c2025-02-03T01:30:27ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/97107909710790Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic LeukemiaHidekazu Nishikii0Naoki Kurita1Atsushi Shinagawa2Tatsuhiro Sakamoto3Manabu Kusakabe4Yasuhisa Yokoyama5Takayasu Kato6Mamiko Sakata-Yanagimoto7Naoshi Obara8Yuichi Hasegawa9Naoya Nakamura10Shigeru Chiba11Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hemato-Oncology, Hitachi General Hospital, Hitachi, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanDepartment of Pathology, Tokai University, Tokyo, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, JapanA 38-year-old woman with aggressive clinical course of chronic lymphocytic leukemia (CLL) was treated with 8 courses of R-CHOP. Clinical remission was achieved, while B-cell clonality remained. Allogeneic hematopoietic stem cell transplantation was performed with reduced intensity conditioning (fludarabine and 2-Gy total body irradiation). However, autologous hematopoietic recovery occurred within a month after the transplant. Nevertheless, B-cell clonality became undetectable at 14 days after transplant, which has been kept so for over 10 years with clinical remission. Cytogenetic analyses were repeatedly performed and demonstrated nonclonal chromosomal aberrations, although the patient did not develop any secondary malignancies. One possible explanation for the clinical course is a very short-term allogeneic immune reaction helping eradication of residual CLL cells.http://dx.doi.org/10.1155/2019/9710790 |
| spellingShingle | Hidekazu Nishikii Naoki Kurita Atsushi Shinagawa Tatsuhiro Sakamoto Manabu Kusakabe Yasuhisa Yokoyama Takayasu Kato Mamiko Sakata-Yanagimoto Naoshi Obara Yuichi Hasegawa Naoya Nakamura Shigeru Chiba Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia Case Reports in Hematology |
| title | Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia |
| title_full | Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia |
| title_fullStr | Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia |
| title_short | Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia |
| title_sort | durable leukemic remission and autologous marrow recovery with random chromosomal abnormalities after allogeneic hematopoietic stem cell transplantation for chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2019/9710790 |
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