Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites

Metabolism and Excretion of 8-O-Acetylharpagide in Rats and Identification of Its Potential Anti-Breast Cancer Active Metabolites

Xinyu Zhao, Sijia Su, Jingna Zhou, Junfeng Gao, Xu Tang, Binyu Wen Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People’s Republic of ChinaCorrespondence: Binyu Wen, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, People’s Republic of China,...

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Bibliographic Details
Main Authors: Zhao X, Su S, Zhou J, Gao J, Tang X, Wen B
Format: Article
Language:English
Published: Dove Medical Press 2025-04-01
Series:Drug Design, Development and Therapy
Subjects:
8-o-acetylharpagide
breast cancer
ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
metabolite
network pharmacology
akt/nf-κb/mmp9 signaling pathway
Online Access:https://www.dovepress.com/metabolism-and-excretion-of-8-o-acetylharpagide-in-rats-and-identifica-peer-reviewed-fulltext-article-DDDT
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