Cepharanthine synergizes with photodynamic therapy for boosting ROS-driven DNA damage and suppressing MTH1 as a potential anti-cancer strategy

Cepharanthine synergizes with photodynamic therapy for boosting ROS-driven DNA damage and suppressing MTH1 as a potential anti-cancer strategy

Objective: Photodynamic therapy (PDT) primarily treats skin diseases or cancer by generating reactive oxygen species (ROS) to damage cellular DNA, yet drug resistance limits its application. To tackle this problem, the present study was carried out to improve the efficacy of chlorin e6 (Ce6)-PDT usi...

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Bibliographic Details
Main Authors: Zi-Yi Yang, Liu-Gen Li, Yi-Lian Xiong, Nan-Nan Chen, Ting-Ting Yu, Hai-Tao Li, Tao Ren, Hui You, Xiao Wang, Tong-Fei Li, Mei-Fang Wang, Jun Hu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Photodiagnosis and Photodynamic Therapy
Subjects:
Photodynamic therapy (PDT)
Cepharanthine (CEP)
MTH1
Drug resistance
DNA damage
Lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1572100023006440
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