Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia

Iron overload promotes myeloid differentiation of normal hematopoietic stem cells and educates macrophage mediated immunosuppression in acute myeloid leukemia

BackgroundThe hematopoietic ecosystem comprises both cellular components such as hematopoietic stem cells (HSCs) and immune cells as well as non-cellular components including iron. Systemic iron overload, which leads to serious complications and affects both patients’ quality of life and overall sur...

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Bibliographic Details
Main Authors: Feifei Yang, Shulin Luo, Dan Yang, Xiaoxi Cui, Dongyue Zhang, Hao Wang, Yifei Li, Wanzhen Xie, Lina Wang, Xiuqun Zhang, Guoguang Zheng, Xuezhong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
iron overload
myeloid differentiation
leukemia-associated macrophages
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626888/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626888/full

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