Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency
Primary immunodeficiencies are rare inherited disorders that may lead to frequent and often severe acute respiratory infections. Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/850831 |
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| author | Marcello Lanari Silvia Vandini Maria Grazia Capretti Tiziana Lazzarotto Giacomo Faldella |
| author_facet | Marcello Lanari Silvia Vandini Maria Grazia Capretti Tiziana Lazzarotto Giacomo Faldella |
| author_sort | Marcello Lanari |
| collection | DOAJ |
| description | Primary immunodeficiencies are rare inherited disorders that may lead to frequent and often severe acute respiratory infections. Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- and B-cell immune response unable to efficaciously neutralize viral replication, with subsequent increased viral shedding and potentially lethal lower respiratory tract infection. Several authors have reported a severe clinical course after RSV infections in infants and children with primary and acquired immunodeficiencies. Environmental prophylaxis is essential in order to reduce the infection during the epidemic season in hospitalized immunocompromised infants. Prophylaxis with palivizumab, a humanized monoclonal antibody against the RSV F protein, is currently recommended in high-risk infants born prematurely, with chronic lung disease or congenital heart disease. Currently however the prophylaxis is not routinely recommended in infants with primary immunodeficiency, although some authors propose the extension of prophylaxis to this high risk population. |
| format | Article |
| id | doaj-art-beccb8d1a8ba431a9c5780605c38cdfd |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-beccb8d1a8ba431a9c5780605c38cdfd2025-02-03T06:07:18ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/850831850831Respiratory Syncytial Virus Infections in Infants Affected by Primary ImmunodeficiencyMarcello Lanari0Silvia Vandini1Maria Grazia Capretti2Tiziana Lazzarotto3Giacomo Faldella4Pediatrics and Neonatology Unit, Imola Hospital, Via Montericco 4, 40026 Imola, ItalyDIMEC, Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Via Massarenti 11, University of Bologna, 40138 Bologna, ItalyDIMEC, Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Via Massarenti 11, University of Bologna, 40138 Bologna, ItalyDIMES, Clinical Microbiology Unit, Laboratory of Virology, St. Orsola-Malpighi Hospital, Via Massarenti 9, University of Bologna, Bologna, ItalyDIMEC, Neonatology and Neonatal Intensive Care Unit, St. Orsola-Malpighi Hospital, Via Massarenti 11, University of Bologna, 40138 Bologna, ItalyPrimary immunodeficiencies are rare inherited disorders that may lead to frequent and often severe acute respiratory infections. Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- and B-cell immune response unable to efficaciously neutralize viral replication, with subsequent increased viral shedding and potentially lethal lower respiratory tract infection. Several authors have reported a severe clinical course after RSV infections in infants and children with primary and acquired immunodeficiencies. Environmental prophylaxis is essential in order to reduce the infection during the epidemic season in hospitalized immunocompromised infants. Prophylaxis with palivizumab, a humanized monoclonal antibody against the RSV F protein, is currently recommended in high-risk infants born prematurely, with chronic lung disease or congenital heart disease. Currently however the prophylaxis is not routinely recommended in infants with primary immunodeficiency, although some authors propose the extension of prophylaxis to this high risk population.http://dx.doi.org/10.1155/2014/850831 |
| spellingShingle | Marcello Lanari Silvia Vandini Maria Grazia Capretti Tiziana Lazzarotto Giacomo Faldella Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency Journal of Immunology Research |
| title | Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency |
| title_full | Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency |
| title_fullStr | Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency |
| title_full_unstemmed | Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency |
| title_short | Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency |
| title_sort | respiratory syncytial virus infections in infants affected by primary immunodeficiency |
| url | http://dx.doi.org/10.1155/2014/850831 |
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