Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.

Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant.

Innate immune responses to vaccine adjuvants based on lipopolysaccharide (LPS), a component of gram-negative bacterial cell walls, are driven by Toll-like receptor (TLR) 4 and adaptor proteins including MyD88 and TRIF, leading to the production of inflammatory cytokines, type I interferons, and chem...

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Main Authors: Rhea N Coler, Sylvie Bertholet, Magdalini Moutaftsi, Jeff A Guderian, Hillarie Plessner Windish, Susan L Baldwin, Elsa M Laughlin, Malcolm S Duthie, Christopher B Fox, Darrick Carter, Martin Friede, Thomas S Vedvick, Steven G Reed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016333&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016333&type=printable

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