Some aspects of gene association with high sport achievements
Most papers on sport genetics identify differences between genotypes of athletes and a control group. It is obvious that the genetic differences should also be among sportsmen with different qualifications. Additionally, athletes’ performance depends not only on their genotypes, but also on the gene...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2017-05-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/957 |
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| author | I. B. Mosse A. V. Kilchevsky L. A. Kundas A. L. Gonchar S. L. Minin K. V. Zhur |
| author_facet | I. B. Mosse A. V. Kilchevsky L. A. Kundas A. L. Gonchar S. L. Minin K. V. Zhur |
| author_sort | I. B. Mosse |
| collection | DOAJ |
| description | Most papers on sport genetics identify differences between genotypes of athletes and a control group. It is obvious that the genetic differences should also be among sportsmen with different qualifications. Additionally, athletes’ performance depends not only on their genotypes, but also on the gene activities, which can be different during the training process in various athletes.The aim of the study was to compare genotypes of athletes with different qualifications and to analyze the change in expression of some genes responsible for the physical performance. Genotypes of 143 elite sportsmen of 18 national teams were analyzed by PCR method. A comparison of the genotypes of Masters of Sports, International Masters of Sports and Honored Masters of Sports showed that the frequencies of favorable gene variants were higher in the genotypes of more qualified athletes; it proves an appropriate genetic potential necessity for high achievements in sports. The analysis of UCP2, HIF1A and MTHFR gene expression changes in response to two-week hypoxiс training was performed on 15 skaters of high qualification. We found that average UCP2 and MTHFR mRNA levels had significantly increased after the training but the expression of the HIF1A gene had reduced. At the same time, individual athlete variability in UCP2, HIF1A and MTHFR gene expression was revealed. Genotype influence on gene expression was shown with the help of the UCP2 gene – its activity was higher in sportsmen with Val/Val than with Val/Ala or Ala/Ala genotypes. Consequently, genotyping and analysis of gene expression is very important for athlete selection and training. |
| format | Article |
| id | doaj-art-beadced6f2e54a0a93e93488f8f965bf |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-beadced6f2e54a0a93e93488f8f965bf2025-02-01T09:58:04ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592017-05-0121329630310.18699/VJ17.247599Some aspects of gene association with high sport achievementsI. B. Mosse0A. V. Kilchevsky1L. A. Kundas2A. L. Gonchar3S. L. Minin4K. V. Zhur5Institute of Genetics and Cytology of NAS of BelarusInstitute of Genetics and Cytology of NAS of BelarusInstitute of Genetics and Cytology of NAS of BelarusInstitute of Genetics and Cytology of NAS of BelarusMinsk City Olympic Reserve Skating CenterInstitute of Genetics and Cytology of NAS of BelarusMost papers on sport genetics identify differences between genotypes of athletes and a control group. It is obvious that the genetic differences should also be among sportsmen with different qualifications. Additionally, athletes’ performance depends not only on their genotypes, but also on the gene activities, which can be different during the training process in various athletes.The aim of the study was to compare genotypes of athletes with different qualifications and to analyze the change in expression of some genes responsible for the physical performance. Genotypes of 143 elite sportsmen of 18 national teams were analyzed by PCR method. A comparison of the genotypes of Masters of Sports, International Masters of Sports and Honored Masters of Sports showed that the frequencies of favorable gene variants were higher in the genotypes of more qualified athletes; it proves an appropriate genetic potential necessity for high achievements in sports. The analysis of UCP2, HIF1A and MTHFR gene expression changes in response to two-week hypoxiс training was performed on 15 skaters of high qualification. We found that average UCP2 and MTHFR mRNA levels had significantly increased after the training but the expression of the HIF1A gene had reduced. At the same time, individual athlete variability in UCP2, HIF1A and MTHFR gene expression was revealed. Genotype influence on gene expression was shown with the help of the UCP2 gene – its activity was higher in sportsmen with Val/Val than with Val/Ala or Ala/Ala genotypes. Consequently, genotyping and analysis of gene expression is very important for athlete selection and training.https://vavilov.elpub.ru/jour/article/view/957athletic performancepcr analysisdna polymorphismsselection programsgene expression |
| spellingShingle | I. B. Mosse A. V. Kilchevsky L. A. Kundas A. L. Gonchar S. L. Minin K. V. Zhur Some aspects of gene association with high sport achievements Вавиловский журнал генетики и селекции athletic performance pcr analysis dna polymorphisms selection programs gene expression |
| title | Some aspects of gene association with high sport achievements |
| title_full | Some aspects of gene association with high sport achievements |
| title_fullStr | Some aspects of gene association with high sport achievements |
| title_full_unstemmed | Some aspects of gene association with high sport achievements |
| title_short | Some aspects of gene association with high sport achievements |
| title_sort | some aspects of gene association with high sport achievements |
| topic | athletic performance pcr analysis dna polymorphisms selection programs gene expression |
| url | https://vavilov.elpub.ru/jour/article/view/957 |
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