Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells.

Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells.

Cell stress adaptation plays a key role in normal development and in various diseases including cancer. Caspases are activated in response to cell stress, and growing evidence supports their function in non-apoptotic cellular processes. A role for effector caspases in promoting stress-induced cytopr...

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Main Authors: Gayathri Samarasekera, Nancy E Go, Courtney Choutka, Jing Xu, Yuka Takemon, Jennifer Chan, Michelle Chan, Shivani Perera, Samuel Aparicio, Gregg B Morin, Marco A Marra, Suganthi Chittaranjan, Sharon M Gorski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003034
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https://doi.org/10.1371/journal.pbio.3003034

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