Deciphering response dynamics and treatment resistance from circulating tumor DNA after CAR T-cells in multiple myeloma

Deciphering response dynamics and treatment resistance from circulating tumor DNA after CAR T-cells in multiple myeloma

Abstract Despite advances in treatments, multiple myeloma (MM) remains an incurable cancer where relapse is common. We developed a circulating tumor DNA (ctDNA) approach in order to characterize tumor genomics, monitor treatment response, and detect early relapse in MM. By sequencing 412 specimens f...

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Main Authors: Hitomi Hosoya, Mia Carleton, Kailee Tanaka, Brian Sworder, Shriya Syal, Bita Sahaf, Alisha M. Maltos, Oscar Silva, Henning Stehr, Vanna Hovanky, George Duran, Tian Zhang, Michaela Liedtke, Sally Arai, David Iberri, David Miklos, Michael S. Khodadoust, Surbhi Sidana, David M. Kurtz
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56486-6
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https://doi.org/10.1038/s41467-025-56486-6

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