Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine

Comprehensive establishment and characterization of orthoxenograft mouse models of malignant peripheral nerve sheath tumors for personalized medicine

Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are soft‐tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. We present the generation and charact...

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Main Authors: Joan Castellsagué, Bernat Gel, Juana Fernández‐Rodríguez, Roger Llatjós, Ignacio Blanco, Yolanda Benavente, Diana Pérez‐Sidelnikova, Javier García‐del Muro, Joan Maria Viñals, August Vidal, Rafael Valdés‐Mas, Ernest Terribas, Adriana López‐Doriga, Miguel Angel Pujana, Gabriel Capellá, Xose S Puente, Eduard Serra, Alberto Villanueva, Conxi Lázaro
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:EMBO Molecular Medicine
Subjects:
MPNST
NF1
patient‐derived tumor xenograft
preclinical mouse models
sorafenib
Online Access:https://doi.org/10.15252/emmm.201404430
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https://doi.org/10.15252/emmm.201404430

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