Mn-doped ZnO thin films as a platform for reagentless uric acid biosensor

Mn-doped ZnO thin films as a platform for reagentless uric acid biosensor

In this study, sol gel technique is used to fabricate manganese (Mn) doped ZnO thin films and further utilize them as a platform for uric acid biosensors. The objective was to introduce manganese into the ZnO matrix to enhance its redox properties, capitalizing on the multivalent nature of manganese...

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Main Authors: Bilasini Devi Naorem, Jatinder Pal Singh, Babita Sharma, Satyam Garg, Athira C, Hashima Sherin, Mahima Momaliya, Muskan, Shubhi Sahu, Arijit Chowdhuri, Mallika Verma, Monika Tomar, Neha Batra
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Chemical Physics Impact
Subjects:
Mediator-free
Mn doped ZnO
Uric acid
Biosensor
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022425000118
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Summary:In this study, sol gel technique is used to fabricate manganese (Mn) doped ZnO thin films and further utilize them as a platform for uric acid biosensors. The objective was to introduce manganese into the ZnO matrix to enhance its redox properties, capitalizing on the multivalent nature of manganese. The Mn-doped thin films of concentrations varying from 3 %,5 %,7 % and 10 % were prepared and further characterized using UV–vis spectroscopy, X-ray diffraction (XRD) spectroscopy, Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM) and cyclic voltammetry (CV) measurements. The ZnO thin films with 7 % doping of Mn exhibited improved redox behaviour, as evident by the distinct redox peaks. In order to immobilise the uricase enzyme, the 7 % Mn doped composition was used, creating a highly sensitive and focused uric acid detection platform. The fabricated biosensor exhibits excellent performance in terms of sensitivity (40 µAmM-1cm-2), selectivity with <5 % deviation found in presence of other known markers present in human sera, and shelf life >12 weeks, enabling precise and sensitive uric acid detection. This study brings to light an alternate approach in developing point of care biosensors using transition metal doped ZnO thin films.
ISSN:2667-0224

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