Novel Tricarbonylrhenium-Anthrapyrazole Complexes with DNA-Binding and Antitumor Properties: In Vitro and In Vivo Pharmacokinetic Studies with <sup>99m</sup>Tc-Analogue

Novel Tricarbonylrhenium-Anthrapyrazole Complexes with DNA-Binding and Antitumor Properties: In Vitro and In Vivo Pharmacokinetic Studies with <sup>99m</sup>Tc-Analogue

Organometallic complexes of <i>fac</i>-tricarbonylrhenium have been shown to exhibit anticancer properties. Anthrapyrazole anticancer agents act as DNA intercalators and topoisomerase IIα inhibitors, leading to double-strand breaks (DBS) and cell cycle arrest. This work involves the synt...

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Bibliographic Details
Main Authors: Georgios Paparidis, Melpomeni Akrivou, George Psomas, Ioannis S. Vizirianakis, Antonios Hatzidimitriou, Catherine Gabriel, Dimosthenis Sarigiannis, Dionysia Papagiannopoulou
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Inorganics
Subjects:
rhenium
tricarbonylrhenium
anthrapyrazole
anthraquinone
DNA-binding studies
cytotoxicity
Online Access:https://www.mdpi.com/2304-6740/12/9/254
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