Investigating the association of traditional and non-traditional tobacco product use with subclinical and clinical cardiovascular disease: The Cross-Cohort Collaboration- Tobacco working group rationale, design, and methodology
While the impact of combustible cigarette smoking on cardiovascular disease (CVD) is well-established, the longitudinal association of non-traditional tobacco products with subclinical and clinical CVD has not been fully explored due to: 1) limited data availability; and 2) the lack of well-phenotyp...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2023-07-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/Investigating-the-association-of-traditional-and-non-traditional-tobacco-product,166517,0,2.html |
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| Summary: | While the impact of combustible cigarette smoking on cardiovascular disease
(CVD) is well-established, the longitudinal association of non-traditional tobacco
products with subclinical and clinical CVD has not been fully explored due to: 1)
limited data availability; and 2) the lack of well-phenotyped prospective cohorts.
Therefore, there is the need for sufficiently powered well-phenotyped datasets
to fully elucidate the CVD risks associated with non-cigarette tobacco products.
The Cross-Cohort Collaboration (CCC)-Tobacco is a harmonized dataset of 23
prospective cohort studies predominantly in the US. A priori defined variables
collected from each cohort included baseline characteristics, details of traditional
and non-traditional tobacco product use, inflammatory markers, and outcomes
including subclinical and clinical CVD. The definitions of the variables in each
cohort were systematically evaluated by a team of two physician-scientists
and a biostatistician. Herein, we describe the method of data acquisition and
harmonization and the baseline sociodemographic and risk profile of participants
in the combined CCC-Tobacco dataset. The total number of participants in
the pooled cohort is 322782 (mean age: 59.7 ± 11.8 years) of which 76% are
women. White individuals make up the majority (73.1%), although there is good
representation of other race and ethnicity groups including African American
(15.6%) and Hispanic/Latino individuals (6.4%). The prevalence of participants
who never smoked, formerly smoked, and currently smoke combustible cigarettes
is 50%, 36%, and 14%, respectively. The prevalence of current and former cigar,
pipe, and smokeless tobacco is 7.3%, 6.4%, and 8.6%, respectively. E-cigarette
use was measured only in follow-up visits of select studies, totaling 1704 former
and current users. CCC-Tobacco is a large, pooled cohort dataset that is uniquely
designed with increased power to expand knowledge regarding the association
of traditional and non-traditional tobacco use with subclinical and clinical CVD,
with extension to understudied groups including women and individuals from
underrepresented racial-ethnic groups. |
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| ISSN: | 1617-9625 |