Development of novel nucleic acid therapy aimed at directly controlling liver fibrosis

Development of novel nucleic acid therapy aimed at directly controlling liver fibrosis

Currently, no drugs directly treat liver fibrosis. Previously, we have shown that treatment with miR-29a-3p improved liver fibrosis in a mouse model. To investigate the effectiveness of nucleic acid therapy at a lower dose, a modified nucleic acid was prepared based on miR-29a-3p. The original micro...

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Bibliographic Details
Main Authors: Tomohiro Umezu, Masakatsu Takanashi, Koji Fujita, Akio Ishikawa, Yuichirou Harada, Yoshinari Matsumoto, Masahiko Kuroda, Yoshiki Murakami
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
liver fibrosis
chronic liver injury
miRNA
drug delivery system
modified oligonucleotide
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124003251
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http://www.sciencedirect.com/science/article/pii/S2162253124003251

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