Calpain 2 Isoform‐Specific Cleavage of Filamin A Enhances HIF1α Nuclear Translocation, Promoting Metastasis in Triple‐Negative Breast Cancer

Calpain 2 Isoform‐Specific Cleavage of Filamin A Enhances HIF1α Nuclear Translocation, Promoting Metastasis in Triple‐Negative Breast Cancer

ABSTRACT Triple‐negative breast cancer (TNBC) remains a challenge due to its aggressive nature and limited therapeutic options. Calpain 2, a member of the calcium‐dependent cysteine protease family, is particularly associated with poor prognosis in TNBC. This study explores the isoform‐specific role...

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Bibliographic Details
Main Authors: Kyung‐Hwa Jeon, Seojeong Park, Eun Seon Pak, Jeong‐Ahn Kim, Yi Liu, Soo‐Yeon Hwang, Younghwa Na, Youngjoo Kwon
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:MedComm
Subjects:
calpain 2
calpain inhibitor
epithelial–mesenchymal transition
metastasis
triple‐negative breast cancer
Online Access:https://doi.org/10.1002/mco2.70147
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https://doi.org/10.1002/mco2.70147

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