Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones

Conventional and non-conventional antigen-binding sites promote the development and function of chronic lymphocytic leukemia stereotyped subset #4 clones

Immunoglobulins (IGs) made by chronic lymphocytic leukemia (CLL) B cells are unique in that they bind themselves (homo-dimerize). This interaction leads to signal transduction with functional consequences that depend on the affinity of homo-dimerization. We have studied the antigen-binding propertie...

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Main Authors: Yun Liu, Dzmitry Padhorny, Rosa Catera, Antonella Nicolo, Xiao-Jie Yan, Stan Xiaogang Li, Anastasia Iatrou, Andrea N. Mazzarello, Noemi Destefani, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Massimo Degano, Paolo P. Ghia, Charles C. Chu, Florian Krammer, Hassan Jumaa, Kostas Stamatopoulos, Dima Kozakov, Nicholas Chiorazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
chronic lymphocytic leukemia
B cell receptor
antigen
antigen binding
autoreactivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607189/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607189/full

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