Effects of Curcumin on Iron Overload in Rats
Background: Iron overload, common in patients with hematological disorders, is a key target in drug development. This study investigated the effects of curcumin on iron overload in rats. Methods: Forty male Wistar rats weighing 139.78 ± 11.95 gm (Mean ± SD) were divided into three equal groups:...
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Knowledge E
2021-12-01
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| Series: | Sudan Journal of Medical Sciences |
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| author | Gülüzar Özbolat Arash Alizadeh Yegani |
| author_facet | Gülüzar Özbolat Arash Alizadeh Yegani |
| author_sort | Gülüzar Özbolat |
| collection | DOAJ |
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Background: Iron overload, common in patients with hematological disorders, is a key target in drug development. This study investigated the effects of curcumin on iron overload in rats.
Methods: Forty male Wistar rats weighing 139.78 ± 11.95 gm (Mean ± SD) were divided into three equal groups: (i) controls; (ii) iron overload group that received six doses of iron dextran 1000 mg/kg–1 by intraperitoneal injections (i.p.); and (iii) iron overload curcumin group that received six doses of curcumin (1000 mg/kg BW by i.p.). In addition to six doses of iron dextran 1000 mg/kg–1 by i.p., we studied the effects of curcumin on liver function enzymes (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]); antioxidant enzymes (malondialdehyde [MDA], total oxidant status [TOS], total antioxidant status [TAS]); hematological parameters (hemoglobin [Hb], hematocrit [Hct], red blood cells [RBC], white blood cells [WBC], mean corpus volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC]); and iron parameters (serum iron profile, transferrin, total iron-binding capacity [TIBC], ferritin, and transferrin saturation [TS%]).
Results: Curcumin caused a significant decrease in the Hct and Hb concentrations in Group III (P < 0.05). It also significantly reduced the serum levels of ALT (52.45 ± 4.51 vs 89.58 ± 4.65 U/L) and AST (148.03 ± 6.47 vs 265.27 ± 13.02 U/L) at the end of the study (P < 0.05). The TIBC, transferrin levels, and TS significantly decreased when the rats were administered curcumin serum iron (P < 0.05). The TAS level significantly increased in Group III in comparison to Group I (the control group) (P < 0.05). At the end of the study, curcumin significantly reduced the serum levels of TOS (12.03 ± 2.8 vs 16.95 ± 5.05 mmol H2O2/L) while the TAS (1.98 ± 0.42 vs 1.06 ± 0.33 mmol Trolox equiv./L) was increased.
Conclusion: The findings of the present study suggest the therapeutic potential of curcumin against iron overload.
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| format | Article |
| id | doaj-art-bd2daa2d3f4f4ab1999b8c8d4ff0e0d8 |
| institution | Kabale University |
| issn | 1858-5051 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Knowledge E |
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| series | Sudan Journal of Medical Sciences |
| spelling | doaj-art-bd2daa2d3f4f4ab1999b8c8d4ff0e0d82025-01-21T11:43:29ZengKnowledge ESudan Journal of Medical Sciences1858-50512021-12-0116410.18502/sjms.v16i4.9944Effects of Curcumin on Iron Overload in RatsGülüzar Özbolat0Arash Alizadeh Yegani1Faculty of Health Science, Sinop University, Sinop, TurkeyDepartment of Pharmacology, Faculty of Veterinary, Mustafa Kemal University, Hatay, Turkey Background: Iron overload, common in patients with hematological disorders, is a key target in drug development. This study investigated the effects of curcumin on iron overload in rats. Methods: Forty male Wistar rats weighing 139.78 ± 11.95 gm (Mean ± SD) were divided into three equal groups: (i) controls; (ii) iron overload group that received six doses of iron dextran 1000 mg/kg–1 by intraperitoneal injections (i.p.); and (iii) iron overload curcumin group that received six doses of curcumin (1000 mg/kg BW by i.p.). In addition to six doses of iron dextran 1000 mg/kg–1 by i.p., we studied the effects of curcumin on liver function enzymes (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]); antioxidant enzymes (malondialdehyde [MDA], total oxidant status [TOS], total antioxidant status [TAS]); hematological parameters (hemoglobin [Hb], hematocrit [Hct], red blood cells [RBC], white blood cells [WBC], mean corpus volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC]); and iron parameters (serum iron profile, transferrin, total iron-binding capacity [TIBC], ferritin, and transferrin saturation [TS%]). Results: Curcumin caused a significant decrease in the Hct and Hb concentrations in Group III (P < 0.05). It also significantly reduced the serum levels of ALT (52.45 ± 4.51 vs 89.58 ± 4.65 U/L) and AST (148.03 ± 6.47 vs 265.27 ± 13.02 U/L) at the end of the study (P < 0.05). The TIBC, transferrin levels, and TS significantly decreased when the rats were administered curcumin serum iron (P < 0.05). The TAS level significantly increased in Group III in comparison to Group I (the control group) (P < 0.05). At the end of the study, curcumin significantly reduced the serum levels of TOS (12.03 ± 2.8 vs 16.95 ± 5.05 mmol H2O2/L) while the TAS (1.98 ± 0.42 vs 1.06 ± 0.33 mmol Trolox equiv./L) was increased. Conclusion: The findings of the present study suggest the therapeutic potential of curcumin against iron overload. https://knepublishing.com/index.php/SJMS/article/view/9944curcuminiron overloadTIBCTASTOSMDA |
| spellingShingle | Gülüzar Özbolat Arash Alizadeh Yegani Effects of Curcumin on Iron Overload in Rats Sudan Journal of Medical Sciences curcumin iron overload TIBC TAS TOS MDA |
| title | Effects of Curcumin on Iron Overload in Rats |
| title_full | Effects of Curcumin on Iron Overload in Rats |
| title_fullStr | Effects of Curcumin on Iron Overload in Rats |
| title_full_unstemmed | Effects of Curcumin on Iron Overload in Rats |
| title_short | Effects of Curcumin on Iron Overload in Rats |
| title_sort | effects of curcumin on iron overload in rats |
| topic | curcumin iron overload TIBC TAS TOS MDA |
| url | https://knepublishing.com/index.php/SJMS/article/view/9944 |
| work_keys_str_mv | AT guluzarozbolat effectsofcurcuminonironoverloadinrats AT arashalizadehyegani effectsofcurcuminonironoverloadinrats |