Sequence-based engineering of pH-sensitive antibodies for tumor targeting or endosomal recycling applications

The engineering of pH-sensitive therapeutic antibodies, particularly for improving effectiveness and specificity in acidic solid-tumor microenvironments, has recently gained traction. While there is a justified need for pH-dependent immunotherapies, current engineering techniques are tedious and lab...

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Bibliographic Details
Main Authors: Wanlei Wei, Traian Sulea
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2404064
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