A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia
Waldenström's macroglobulinemia is a B-cell neoplasm characterized by infiltration of the bone marrow by a lymphoplasmacytic infiltrate and an IgM monoclonal gammopathy. It is an uncommon disease with overall incidence of approximately 3 per million persons per year, accounting for approximatel...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2012/271407 |
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| author | Bhawna Sethi K. S. Butola Yogesh Kumar |
| author_facet | Bhawna Sethi K. S. Butola Yogesh Kumar |
| author_sort | Bhawna Sethi |
| collection | DOAJ |
| description | Waldenström's macroglobulinemia is a B-cell neoplasm characterized by infiltration of the bone marrow by a lymphoplasmacytic infiltrate and an IgM monoclonal gammopathy. It is an uncommon disease with overall incidence of approximately 3 per million persons per year, accounting for approximately 1% to 2% of all hematologic cancers. It has only one-sixth the estimated prevalence of plasma cell myeloma. Disease symptoms can be due to infiltration of bone marrow and other tissue sites by malignant lymphoplasmacytic cells or due to the effects of elevated serum IgM levels. However, patients may present with constitutional symptoms only or may be asymptomatic. In our case, patient presented with chief complaints of fatigability and dyspnoea and was misdiagnosed as plasma cell leukemia on peripheral blood film and bone marrow morphology, but turned out to be a case of Waldenström's macroglobulinemia on cytoflorometry. The patient was referred for chemotherapy but expired on 10th day of admission. The suspected cause of death was cardiorespiratory failure. |
| format | Article |
| id | doaj-art-bd11bea88b4d4f68a0531ddbd28d99ae |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-bd11bea88b4d4f68a0531ddbd28d99ae2025-02-03T01:23:28ZengWileyCase Reports in Pathology2090-67812090-679X2012-01-01201210.1155/2012/271407271407A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell LeukemiaBhawna Sethi0K. S. Butola1Yogesh Kumar2Department of Pathology, VCSGGMS & RI Srinagar, Pauri Garhwal, Uttarakhand, IndiaDepartment of Medicine, VCSGGMS & RI Srinagar, Pauri Garhwal, Uttarakhand, IndiaDepartment of Ophthalmology, VCSGGMS & RI Srinagar, Pauri Garhwal, Uttarakhand, IndiaWaldenström's macroglobulinemia is a B-cell neoplasm characterized by infiltration of the bone marrow by a lymphoplasmacytic infiltrate and an IgM monoclonal gammopathy. It is an uncommon disease with overall incidence of approximately 3 per million persons per year, accounting for approximately 1% to 2% of all hematologic cancers. It has only one-sixth the estimated prevalence of plasma cell myeloma. Disease symptoms can be due to infiltration of bone marrow and other tissue sites by malignant lymphoplasmacytic cells or due to the effects of elevated serum IgM levels. However, patients may present with constitutional symptoms only or may be asymptomatic. In our case, patient presented with chief complaints of fatigability and dyspnoea and was misdiagnosed as plasma cell leukemia on peripheral blood film and bone marrow morphology, but turned out to be a case of Waldenström's macroglobulinemia on cytoflorometry. The patient was referred for chemotherapy but expired on 10th day of admission. The suspected cause of death was cardiorespiratory failure.http://dx.doi.org/10.1155/2012/271407 |
| spellingShingle | Bhawna Sethi K. S. Butola Yogesh Kumar A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia Case Reports in Pathology |
| title | A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia |
| title_full | A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia |
| title_fullStr | A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia |
| title_full_unstemmed | A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia |
| title_short | A Diagnostic Dilemma: Waldenström's Macroglobulinemia/Plasma Cell Leukemia |
| title_sort | diagnostic dilemma waldenstrom s macroglobulinemia plasma cell leukemia |
| url | http://dx.doi.org/10.1155/2012/271407 |
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