Interaction of GPER-1 with the endocrine signaling axis in breast cancer
G Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as a key player in breast cancer development and progression. In addition to its direct influence on estrogen signaling, a crucial interaction between GPER-1 and the hypothalamic-pituitary-gonadal (HPG) a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1494411/full |
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| author | Luis Molina Calistro Yennyfer Arancibia Marcela Alejandra Olivera Sigrid Domke Rodrigo Flavio Torres |
| author_facet | Luis Molina Calistro Yennyfer Arancibia Marcela Alejandra Olivera Sigrid Domke Rodrigo Flavio Torres |
| author_sort | Luis Molina Calistro |
| collection | DOAJ |
| description | G Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as a key player in breast cancer development and progression. In addition to its direct influence on estrogen signaling, a crucial interaction between GPER-1 and the hypothalamic-pituitary-gonadal (HPG) axis has been evidenced. The novel and complex relationship between GPER-1 and HPG implies a hormonal regulation with important homeostatic effects on general organ development and reproductive tissues, but also on the pathophysiology of cancer, especially breast cancer. Recent research points to a great versatility of GPER-1, interacting with classical estrogen receptors and with signaling pathways related to inflammation. Importantly, through its activation by environmental and synthetic estrogens, GPER-1 is associated with hormone therapy resistance in breast cancer. These findings open new perspectives in the understanding of breast tumor development and raise the possibility of future applications in the design of more personalized and effective therapeutic approaches. |
| format | Article |
| id | doaj-art-bd058f97ea0b418a8d49aff64e93cc9b |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-bd058f97ea0b418a8d49aff64e93cc9b2025-01-28T09:22:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.14944111494411Interaction of GPER-1 with the endocrine signaling axis in breast cancerLuis Molina Calistro0Yennyfer Arancibia1Marcela Alejandra Olivera2Sigrid Domke3Rodrigo Flavio Torres4Facultad de Medicina y Ciencia, Universidad San Sebastián, Puerto Montt, ChileFacultad de Medicina y Ciencia, Universidad San Sebastián, Puerto Montt, ChileFacultad de Medicina y Ciencia, Universidad San Sebastián, Puerto Montt, ChileFacultad de Ciencias para el cuidado de la salud, Universidad San Sebastián, Puerto Montt, ChileFacultad de Medicina y Ciencia, Universidad San Sebastián, Puerto Montt, ChileG Protein-Coupled Estrogen Receptor 1 (GPER-1) is a membrane estrogen receptor that has emerged as a key player in breast cancer development and progression. In addition to its direct influence on estrogen signaling, a crucial interaction between GPER-1 and the hypothalamic-pituitary-gonadal (HPG) axis has been evidenced. The novel and complex relationship between GPER-1 and HPG implies a hormonal regulation with important homeostatic effects on general organ development and reproductive tissues, but also on the pathophysiology of cancer, especially breast cancer. Recent research points to a great versatility of GPER-1, interacting with classical estrogen receptors and with signaling pathways related to inflammation. Importantly, through its activation by environmental and synthetic estrogens, GPER-1 is associated with hormone therapy resistance in breast cancer. These findings open new perspectives in the understanding of breast tumor development and raise the possibility of future applications in the design of more personalized and effective therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fendo.2025.1494411/fullGPER-1estrogenhypothalamic-pituitary-gonadal axisbreast cancerendocrine resistancepersonalized medicine |
| spellingShingle | Luis Molina Calistro Yennyfer Arancibia Marcela Alejandra Olivera Sigrid Domke Rodrigo Flavio Torres Interaction of GPER-1 with the endocrine signaling axis in breast cancer Frontiers in Endocrinology GPER-1 estrogen hypothalamic-pituitary-gonadal axis breast cancer endocrine resistance personalized medicine |
| title | Interaction of GPER-1 with the endocrine signaling axis in breast cancer |
| title_full | Interaction of GPER-1 with the endocrine signaling axis in breast cancer |
| title_fullStr | Interaction of GPER-1 with the endocrine signaling axis in breast cancer |
| title_full_unstemmed | Interaction of GPER-1 with the endocrine signaling axis in breast cancer |
| title_short | Interaction of GPER-1 with the endocrine signaling axis in breast cancer |
| title_sort | interaction of gper 1 with the endocrine signaling axis in breast cancer |
| topic | GPER-1 estrogen hypothalamic-pituitary-gonadal axis breast cancer endocrine resistance personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1494411/full |
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