Quinoline conjugated 2-azetidinone derivatives as prospective anti-breast cancer agents: In vitro antiproliferative and anti-EGFR activities, molecular docking and in-silico drug likeliness studies

Quinoline conjugated 2-azetidinone derivatives as prospective anti-breast cancer agents: In vitro antiproliferative and anti-EGFR activities, molecular docking and in-silico drug likeliness studies

Two series [1–8 (series-1) and 9–16 (series-2)] of quinoline conjugated 2-azetidinones were evaluated for their antiproliferative potential against breast cancer cell lines MCF7 and MDA-MB-231 respectively. All the compounds were more active towards against MCF7 than MDA-MB-231 cancer cell lines and...

Full description

Saved in:
Bibliographic Details
Main Authors: K. Govindarao, N. Srinivasan, R. Suresh, R.K. Raheja, Sivakumar Annadurai, Richie R. Bhandare, Afzal B. Shaik
Format: Article
Language:English
Published: Springer 2022-05-01
Series:Journal of Saudi Chemical Society
Subjects:
2-Azetidinones
EGFR kinase
MCF-7
MDA-MB-231
Quinoline
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610322000539
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S1319610322000539

Similar Items