Real-time imaging reveals radiation-induced intratumor apoptosis via nutrient and oxygen deprivation following vascular damage

Real-time imaging reveals radiation-induced intratumor apoptosis via nutrient and oxygen deprivation following vascular damage

Radiotherapy exerts significant effects on the tumor microenvironment. Radiation is known to induce direct tumor cell death through intrinsic factors (e.g., DNA repair activity and p53-mediated radiation sensitivity). It also induces indirect cell death by altering the tumor microenvironment. Howeve...

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Bibliographic Details
Main Authors: Go Kagiya, Ryohei Ogawa, Toshihide Matsumoto, Fuminori Hyodo, Nanako Abe, Ami Yuzawa, Haru Takeuchi, Miki Aoyagi, Ayaka Sato, Kei Yamashita, Masanori Hatashita
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
cell death
apoptosis
protein trans-splicing
apoptosis imaging reporter
split-luciferase reconstitution
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000669
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