Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling

Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling

Background: High-grade endometrial cancer (EC) has a poor prognosis, but molecular classification-based treatments present new therapeutic opportunities. Antibody-drug conjugates (ADC) emerge as promising tools, yet a deeper understanding of antigen dynamics, optimal therapeutic sequencing, and resi...

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Bibliographic Details
Main Authors: Sho Sato, Shigehiro Yagishita, Hiroshi Yoshida, Daisuke Shintani, Aiko Ogasawara, Tadaaki Nishikawa, Masanori Yasuda, Keiji Furuuchi, Toshimitsu Uenaka, Akinobu Hamada, Kosei Hasegawa
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Endometrial cancer
patient-derived xenograft (PDX)
antibody-drug conjugate (ADC)
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000375
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