A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT
Abstract Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscri...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2019-10-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | http://link.springer.com/article/10.1186/s40463-019-0369-0 |
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| _version_ | 1832544153009913856 |
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| author | Scott Kohlert Laurie McLean Dimitrios Scarvelis Calvin Thompson |
| author_facet | Scott Kohlert Laurie McLean Dimitrios Scarvelis Calvin Thompson |
| author_sort | Scott Kohlert |
| collection | DOAJ |
| description | Abstract Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication. |
| format | Article |
| id | doaj-art-bc97484c00b74f28b186ec34f9b8a292 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-bc97484c00b74f28b186ec34f9b8a2922025-02-03T10:54:12ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162019-10-014811510.1186/s40463-019-0369-0A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOTScott Kohlert0Laurie McLean1Dimitrios Scarvelis2Calvin Thompson3ENT Associates of East TexasDepartment of Otolaryngology – Head and Neck Surgery The Ottawa Hospital, University of OttawaDepartment of Medicine, University of OttawaCanada. Hyperbaric Medicine Unit The Ottawa HospitalAbstract Cold agglutinin disease (CAD) is a rare condition leading to blood agglutination and autoimmune hemolytic anemia. Cutaneous ischemia resulting from CAD in the head and neck is uncommon. Treatment regimens and outcomes vary widely in the literature and no clear protocol exists. This manuscript describes a patient with CAD who developed severe ischemia of the nose that resolved completely without sequellae following a medical regimen of aspirin, low molecular weight heparin, nitroglycerin ointment and hyperbaric oxygen therapy (HBOT). To our knowledge, this is the first reported case where nitroglycerin ointment or HBOT was successfully employed in the treatment of this complication.http://link.springer.com/article/10.1186/s40463-019-0369-0Nasal ischemiaAcrocyanosisCold agglutinin diseaseHyperbaric oxygen |
| spellingShingle | Scott Kohlert Laurie McLean Dimitrios Scarvelis Calvin Thompson A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT Journal of Otolaryngology - Head and Neck Surgery Nasal ischemia Acrocyanosis Cold agglutinin disease Hyperbaric oxygen |
| title | A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT |
| title_full | A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT |
| title_fullStr | A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT |
| title_full_unstemmed | A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT |
| title_short | A case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including HBOT |
| title_sort | case report of severe nasal ischemia from cold agglutinin disease and a novel treatment protocol including hbot |
| topic | Nasal ischemia Acrocyanosis Cold agglutinin disease Hyperbaric oxygen |
| url | http://link.springer.com/article/10.1186/s40463-019-0369-0 |
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