CCT8 drives colorectal cancer progression via the RPL4-MDM2-p53 axis and immune modulation

CCT8 drives colorectal cancer progression via the RPL4-MDM2-p53 axis and immune modulation

Abstract Purpose Colorectal cancer (CRC) ranks high in global mortality, emphasizing the need for effective interventions. The aim of the research is to elucidate the oncogenic role of CCT8 in CRC and its interaction with RPL4 in the RPL4-MDM2-p53 axis. Methods TIMER 2.0, TCGA, and GTEx databases we...

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Bibliographic Details
Main Authors: Yangyang Teng, Hao Lin, Zijian Lin, Xichen Li, Yejiao Ruan, Binhui Pan, Jinlin Ge, Yuesheng Zhu, Daopo Lin, Qingji Ying, Zhenzhai Cai, Xuanping Xia
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Medical Genomics
Subjects:
CCT8
RPL4
Colorectal cancer
Immune infiltration
p53 signaling pathway
Online Access:https://doi.org/10.1186/s12920-025-02133-4
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https://doi.org/10.1186/s12920-025-02133-4

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