The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression

The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression

BackgroundCutaneous T-cell lymphoma (CTCL) is a heterogeneous group of T-cell lymphomas characterized with the presence of clonal malignant T cells. Mycosis fungoides (MF) is the most common type of CTCL. However, the pathogenesis of MF and the role of the tumor microenvironment (TME) remain unclear...

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Main Authors: Yige Zhao, Yong Li, Panpan Wang, Mengyan Zhu, Jiaqi Wang, Bo Xie, Chenyu Tang, Yangyang Ma, Shiwen Wang, Sha Jin, Jinhui Xu, Zhao Li, Xiaoyan Zhang, Liuyu Li, Xiuzu Song, Ping Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
mycosis fungoides (MF)
cutaneous T cell lymphoma (CTCL)
tissue resident memory T cell (TRM)
cancer-associated fibroblast (CAF)
tumor microenvironment
SOX4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1474564/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1474564/full

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