Food Effect and Formulation: How Soluble Fillers Affect the Disintegration and Dissolution of Tablets in Viscous Simulated Fed State Media

Food Effect and Formulation: How Soluble Fillers Affect the Disintegration and Dissolution of Tablets in Viscous Simulated Fed State Media

The food-induced viscosity of the media can alter tablet disintegration and eventually the release of the drug it contains. The extent of this retardation depends on tablet formulation factors, such as the solubility of its excipients. <b>Objectives</b>: This research aimed to study the...

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Bibliographic Details
Main Authors: Muhammad Farooq Umer, Valentin Stahl, Jozef Al-Gousous, Thomas Nawroth, Wei-Jhe Sun, Fang Wu, Wenlei Jiang, Zongming Gao, Peter Langguth
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
food effect
tablet fillers
solubility
media viscosity
fed state
water uptake
Online Access:https://www.mdpi.com/1999-4923/17/5/567
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