Impact of Solvent-Mediated Phase Transitions by Artificial Gastrointestinal Buffers on Efavirenz Polymorphs

Impact of Solvent-Mediated Phase Transitions by Artificial Gastrointestinal Buffers on Efavirenz Polymorphs

The implications of various pH solutions in the gastrointestinal fluid system as solvent-mediated phase transitions on concurrent polymorphism transformation, notably metastable polymorphic forms of Efavirenz (EFV), has never been investigated. The impact will be shifting in the solubility and cryst...

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Bibliographic Details
Main Authors: Yoga Windhu Wardhana, Eli Nuraisyah, Angga Prawira Kautsar, Patihul Husni, Arif Budiman, Anis Yohana Chaerunisaa
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Crystals
Subjects:
efavirenz
metastable polymorphs
solvent-mediated transitions
solubility
crystallinity index
artificial gastrointestinal buffers
Online Access:https://www.mdpi.com/2073-4352/15/1/48
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