Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells

Inhibition of Glutamate‐to‐Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells

Abstract Colorectal cancer (CRC) cells display remarkable adaptability, orchestrating metabolic changes that confer growth advantages, pro‐tumor microenvironment, and therapeutic resistance. One such metabolic change occurs in glutamine metabolism. Colorectal tumors with high glutaminase (GLS) expre...

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Main Authors: Tao Yu, Kevin Van der Jeught, Haiqi Zhu, Zhuolong Zhou, Samantha Sharma, Sheng Liu, Haniyeh Eyvani, Ka Man So, Naresh Singh, Jia Wang, George E. Sandusky, Yunlong Liu, Mateusz Opyrchal, Sha Cao, Jun Wan, Chi Zhang, Xinna Zhang
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
colorectal cancer
glutamine metabolism
immune checkpoint blockade
immunoproteasome
MHC‐I antigen presentation
single‐cell flux estimation analysis
Online Access:https://doi.org/10.1002/advs.202310308
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https://doi.org/10.1002/advs.202310308

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