Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation

Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation

Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the host innate immune response to promote its replication. The ubiquitin–proteasome system (UPS) and ISGylation both play roles in modulating host innate immunity. Within this process, ISG15-conjugating enzyme E2L6 (UBE2L...

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Bibliographic Details
Main Authors: Zhenbang Zhu, Lulu Chen, Meng Zhang, Qianwen Lin, Yifan Yan, Wenqiang Wang, Wei Wen, Zhendong Zhang, Xiangdong Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Veterinary Research
Subjects:
PRRSV
NSP5
UBE2L6
ISGylation
innate immune response
Online Access:https://doi.org/10.1186/s13567-025-01558-0
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https://doi.org/10.1186/s13567-025-01558-0

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